Endocrine Abstracts

Introduction: Pats with Klinefelter Syndrome (KS) have elevated morbidity and mortality due to several reasons. Yet, there is no connection between KS and male-to-female sex change.Case: A 74-year-old man was sent for endocrine work-up prior to surgery due to gynecomastia. The patient had lived as a man-to-woman transgender for many years. He was told not to qualify for a transgender surgical approach when he was 55 years old. He took estradiol substitut...

Background: Innate, isolated hypogonadotropic hypogonadism is a rare disease and results in men in cryptorchidism and failed puberty. Migration leads to diagnosis of the disease also in developed countries only in adults.Case: A 28-year-old man was sent for endocrine workup because of failed development of primary sexual characteristics and missing secondary sex characteristics. He grew up in a rural place in Sri Lanka, his brothers and sisters developed...

Background: Primary adrenal lymphoma (PAL) is a rare cause of primary adrenal insufficiency (PAI). Most often patients present with unspecific symptoms. Bilateral adrenal enlargement with signs and symptoms of PAI are clues, percutaneous biopsy after having excluded pheochromocytoma in a situation of high suspicion is diagnostic. Most of PAL are highly malignant B-cell lymphomas with a bad prognosis.Case: A 71-year-old patient was sent for endocrine work...

Introduction: Thyreotropin (TSH) is a glycoprotein containing an alpha-subunit similar to other glycoproteins (LH, FSH, ACTH, HCG) and a unique beta-subunit which reacts with the alpha-subunit in binding to the TSH-receptor. Low TSH levels are usually evidence of primary hyperthyreoidism as in Graves diseases/ toxic goiter or thyroiditis, or a result of secondary hypothyroidism in case of diseases of the pituitary gland. This case shows a rare variant causing apparently low TS...

Introduction: We describe a case of a 32 year old woman with bilateral carotid body tumours as initial finding of a paraganglioma syndrome type 1.Case: A 32-year old previously healthy mother was referred because of bilateral neck swelling, presumably lymphadenopathy, associated with recurrent upper respiratory tract infections during the past year. Cervical ultrasound raised the suspicion for bilateral carotid body tumours which were confirmed by MR-ima...